![]() ![]() doi:10.1002/3īahit MC, Kochar A, Granger CB. First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension. ![]() Angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs).Ĭhen YJ, Li LJ, Tang WL, et al. Īsenjo RB, Bueno H, McIntosh M, European Society of Cardiology. Angioedema: Very rarely, people taking ACE inhibitors can experience angioedema, a severe allergic-like reaction that can become quite dangerous.While this effect is usually very modest and not medically significant, in about 3% of people, potassium levels can become too high. High blood potassium (hyperkalemia): ACE inhibitors can increase blood potassium levels.For this reason, kidney function (blood tests) should be monitored in people who have kidney disease and are beginning ACE inhibitors. ![]() Impaired kidney function: Especially in people who have underlying kidney disease, the use of ACE inhibitors can further reduce kidney function.This problem can usually be avoided by starting with a low dose and gradually building up to higher doses. Hypotension (low blood pressure): ACE inhibitors may reduce blood pressure too much, producing symptoms of weakness, dizziness, or syncope (temporary loss of consciousness).While not a dangerous problem, this side effect can be bothersome and usually requires discontinuation of the drug. Cough: The most prominent side effect of ACE inhibitors is a dry, hacking cough, which may be seen in up to 20% of people given these drugs. ![]()
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